(S,R,S)-AHPC-C4-NH2 hydrochloride( VH032-C4-NH2 hydrochloride | VHL Ligand-Linker Conjugates 13 | E3 ligase Ligand-Linker Conjugates 28 )

Catalog No. M27010 CAS No. 2245697-83-8

COA

Datasheet

HNMR

HPLC

MSDS

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Product Name

(S,R,S)-AHPC-C4-NH2 hydrochloride
Note

Research use only, not for human use.
Brief Description

(S,R,S)-AHPC-C4-NH2 hydrochloride is a synthesized E3 ligase ligand-linker conjugate incorporating the (S,R,S)-AHPC based VHL ligand and a linker.
Description

(S,R,S)-AHPC-C4-NH2 hydrochloride is a synthesized E3 ligase ligand-linker conjugate incorporating the (S,R,S)-AHPC based VHL ligand and a linker.(In Vitro):PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins. PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein.
In Vitro

PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins.
In Vivo

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Synonyms

VH032-C4-NH2 hydrochloride | VHL Ligand-Linker Conjugates 13 | E3 ligase Ligand-Linker Conjugates 28
Pathway

Others
Target

Other Targets
Recptor

LIN28
Research Area

——
Indication

——

CAS Number

2245697-83-8
Formula Weight

566.16
Molecular Formula

C27H40ClN5O4S
Purity

>98% (HPLC)
Solubility

In Vitro:?DMSO : ≥ 109.6 mg/mL (193.58 )
SMILES

O=C(N[C@@H](C(C)(C)C)C(N1C[C@H](O)C[C@H]1C(NCC2=CC=C(C=C2)C3=C(C)N=CS3)=O)=O)CCCCN.[H]Cl
Chemical Name

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1.VG D’Agostino, et al. Screening Approaches for Targeting Ribonucleoprotein Complexes: A New Dimension for Drug Discovery. Slas Discovery, 2019.

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